Maize is important in emerging economies being the primary staple in sub-Saharan Africa and the second most important grain in Asia. Genetically modified (GM) maize is widely planted globally and has been proven to have benefits such as reduced pesticide application, increased grain yield, better grain quality, and higher farmer income. GM maize is a viable option to help meet the food security and income needs in emerging economies. However, its adoption in Asia and Africa is still limited. Using the near two decades of experience with GM maize in The Philippines, this policy paper seeks to illustrate the issues and lessons learned regarding this technology. It is intended for policymakers, legislators, and policy advisors such as academicians and researchers who are involved in proposing new policy instruments, or revisions to existing policies related to GM crop adoption. If GM maize adoption is considered, or rather any other GM crop, governments will need to invest in science-based regulations and expertise, a public awareness program, post-release monitoring, if required, and continued capacity building to address any unique emerging challenges.